Water → N-(3-bromobenzyl)acetamide

HRID 1059218

반응식

HRID 1059218 반응식
Cl.[Br:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH2:6][NH2:7].[C:11](OC(=O)C)(=[O:13])[CH3:12].O.C(OCC)(=O)C>N1C=CC=CC=1>[Br:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH2:6][NH:7][C:11](=[O:13])[CH3:12]

참가 물질

6

반응물 4

HCID 962WaterHCID 7918Acetic AnhydrideHCID 8857Ethyl AcetateHCID 27249803-Bromobenzylamine hydrochloride

생성물 1

HCID 12175281N-(3-bromobenzyl)acetamide

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

To a solution of 3-bromobenzylamine hydrochloride (5.20 g) in pyridine (30 ml) was added acetic anhydride (3.2 ml) at 0° C. and the mixture was stirred at room temperature for 24 h. Water and ethyl acetate were added to the reaction mixture for partitioning, and the organic layer was washed with 1N hydrochloric acid, aqueous sodium hydrogen carbonate and brine, dried (magnesium sulfate) and concentrated under reduced pressure. The residue was recrystallized from hexane-ethyl acetate to give the title compound (4.00 g) as colorless needle crystals.

후처리

  1. customfor partitioning
  2. washthe organic layer was washed with 1N hydrochloric acid, aqueous sodium hydrogen carbonate and brine
  3. dry with materialdried (magnesium sulfate)
  4. concentrationconcentrated under reduced pressure
  5. customThe residue was recrystallized from hexane-ethyl acetate

출처 및 근거

ORD 기록
ord-35cf1564147845648b941737314ce4d1
출처 데이터셋
uspto-grants-2003_02
특허 번호
US06518257B1

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