Ammonia → 10H-Pyrazino[2,3-b][1,4]benzothiazine-8-methanol

HRID 1059303노트

반응식

HRID 1059303 반응식
[NH2:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[S:10][C:11]1[C:16](Cl)=[N:15][CH:14]=[CH:13][N:12]=1)[CH2:5][OH:6].Cl.N>CO>[N:15]1[C:16]2[NH:1][C:2]3[CH:3]=[C:4]([CH2:5][OH:6])[CH:7]=[CH:8][C:9]=3[S:10][C:11]=2[N:12]=[CH:13][CH:14]=1

참가 물질

5

반응물 3

HCID 222AmmoniaHCID 313Hydrochloric AcidHCID 235641353-Amino-4-[(3-chloropyrazin-2-yl)thio]benzyl alcohol

생성물 1

HCID 1094429210H-Pyrazino[2,3-b][1,4]benzothiazine-8-methanol수율 96.9%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To 1.47 g of 3-amino-4-[(3-chloropyrazin-2-yl)thio]benzyl alcohol were added 20 ml of methanol and 0.45 ml of conc. hydrochloric acid and the resulting mixture was heated under reflux for 30 minutes. Then the reaction mixture was made alkaline by adding ice-water and aqueous ammonia. The precipitate was collected by filtration and dried to thereby give 1.23 g of the title compound as yellow crystals.

후처리

  1. temperaturethe resulting mixture was heated
  2. temperatureunder reflux for 30 minutes
  3. filtrationThe precipitate was collected by filtration
  4. customdried

출처 및 근거

ORD 기록
ord-b7887816f108477fa3562fcf3a99e0b5
출처 데이터셋
uspto-grants-2003_02
특허 번호
US06518423B1

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