반응식
[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([C:14]#[N:15])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:16].[CH3:17][OH:18]>>[ClH:16].[ClH:16].[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([C:14](=[NH:15])[O:18][CH3:17])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1참가 물질
4
실험 절차
A solution of 20 g of 1-benzylpiperidine-4-carbonitrile in a mixture of dry dichlolomethane (200 ml) with methanol (30 ml) was cooled and saturated with a hydrogen chloride gas while maintaining the reaction system at 0° C. or below. After allowing to stand for 4 hours at 0° C., the solvent was distilled off under reduced pressure at room temperature or below and the residue was diluted with ethyl acetate. The colorless crystals thus obtained were ground, filtered and washed with ethyl acetate to thereby give 23.6 g of the title compound.
후처리
- temperaturewhile maintaining the reaction system at 0° C. or below
- distillationthe solvent was distilled off under reduced pressure at room temperature or below
- additionthe residue was diluted with ethyl acetate
- customThe colorless crystals thus obtained
- filtrationfiltered
- washwashed with ethyl acetate
출처 및 근거
- ORD 기록
- ord-b1a50a6a66eb4d06b1dfd02973992f7f
- 출처 데이터셋
- uspto-grants-2003_02
- 특허 번호
- US06518423B1
연결된 노트
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