N-Ethylmaleimide → 2-Azido-n-ethylsuccinimide

HRID 1059488노트

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HRID 1059488 반응식
[CH2:1]([N:3]1[C:7](=[O:8])[CH:6]=[CH:5][C:4]1=[O:9])[CH3:2].[NH:10]=[N+:11]=[N-:12].C1(=O)NC(=O)C=C1>C1(C)C=CC=CC=1>[N:10]([CH:5]1[CH2:6][C:7](=[O:8])[N:3]([CH2:1][CH3:2])[C:4]1=[O:9])=[N+:11]=[N-:12]

참가 물질

5

반응물 3

HCID 4362N-EthylmaleimideHCID 10935Maleimide2회HCID 24530Hydrazoic acid

생성물 1

HCID 101763002-Azido-n-ethylsuccinimide수율 93%

시약·촉매·용매 1

HCID 1140Toluene용매

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온도
-30 °C

실험 절차

A solution in toluene of N-ethylmaleimide, HN3 (excess relative to the maleimide), and the (salen)AlN3 catalyst depicted above (10 mol % relative to the maleimide) was maintained at −30° C. for 18 h. After a standard quench and work-up of the reaction mixture, the crude material was purified to yield 2-azido-N-ethylsuccinimide (93%, 93% ee).

후처리

  1. customAfter a standard quench
  2. customwork-up of the reaction mixture, the crude material was purified

출처 및 근거

ORD 기록
ord-6c57a816806d4646804325a4aacefeaa
출처 데이터셋
uspto-grants-2003_02
특허 번호
US06521561B1

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