Hydrochloric Acid → 2-(4-Isopropylphenyl)propylamine hydrochloride

HRID 1059504노트

반응식

HRID 1059504 반응식
[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([CH:10]([CH3:13])[C:11]#[N:12])=[CH:6][CH:5]=1)([CH3:3])[CH3:2].B.CSC.[ClH:18]>O1CCCC1.CO>[ClH:18].[CH:1]([C:4]1[CH:5]=[CH:6][C:7]([CH:10]([CH3:13])[CH2:11][NH2:12])=[CH:8][CH:9]=1)([CH3:3])[CH3:2]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 12423031(Dimethyl sulfide)trihydroboronHCID 136820102-[4-(Propan-2-yl)phenyl]propanenitrile

생성물 1

HCID 218934972-(4-Isopropylphenyl)propylamine hydrochloride수율 73%

시약·촉매·용매 2

HCID 887Methanol용매HCID 8028Tetrahydrofuran용매

실험 절차

In a 100 ml flask, fitted with a condenser, 2-(4-isopropylphenyl) propionitrile 1.90 g (11.0 mmol) was dissolved in tetrahydrofuran (70 ml) under a nitrogen atmosphere. Borane-methyl sulfide complex (10.0-10.2 M in tetrahydrofuran, 1.20 ml, 12.1 mmol) was added to the solution and the mixture heated to reflux for 3 hours. The solution was cooled to ambient temperature and a saturated solution of hydrochloric acid in methanol added slowly until a white precipitate formed. The solvent was removed in vacuo and the resulting white solid triturated (×4) with diethyl ether. Drying under vacuo gave 1.76 g (73%) of the title compound.

후처리

  1. customIn a 100 ml flask, fitted with a condenser
  2. temperaturethe mixture heated
  3. temperatureto reflux for 3 hours
  4. customformed
  5. customThe solvent was removed in vacuo
  6. customthe resulting white solid triturated (×4) with diethyl ether
  7. customDrying under vacuo

출처 및 근거

ORD 기록
ord-7ad13324e63944c19489b8480b66536a
출처 데이터셋
uspto-grants-2003_02
특허 번호
US06521605B1

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