tert-butyl N-{[4-(aminomethyl)phenyl]methyl}carbamate → N-(tert-butoxycarbonyl)-N'-[(5-isoquinolyl)sulfonyl]-1,4-xylylenediamine

HRID 10600

반응식

HRID 10600 반응식
Cl.[CH:2]1[C:11]2[CH:10]=[CH:9][CH:8]=[C:7]([S:12](Cl)(=[O:14])=[O:13])[C:6]=2[CH:5]=[CH:4][N:3]=1.[C:16]([O:20][C:21]([NH:23][CH2:24][C:25]1[CH:32]=[CH:31][C:28]([CH2:29][NH2:30])=[CH:27][CH:26]=1)=[O:22])([CH3:19])([CH3:18])[CH3:17]>>[C:16]([O:20][C:21]([NH:23][CH2:24][C:25]1[CH:32]=[CH:31][C:28]([CH2:29][NH:30][S:12]([C:7]2[CH:8]=[CH:9][CH:10]=[C:11]3[C:6]=2[CH:5]=[CH:4][N:3]=[CH:2]3)(=[O:14])=[O:13])=[CH:27][CH:26]=1)=[O:22])([CH3:19])([CH3:17])[CH3:18]

참가 물질

3

반응물 2

HCID 3354775tert-butyl N-{[4-(aminomethyl)phenyl]methyl}carbamateHCID 13116932Isoquinoline-5-sulfonyl chloride hydrochloride

생성물 1

HCID 69523966N-(tert-butoxycarbonyl)-N'-[(5-isoquinolyl)sulfonyl]-1,4-xylylenediamine수율 82.7%

실험 절차

According to Reference Example 5, Step B, a reaction was performed by using isoquinoline-5-sulfonyl chloride hydrochloride (10 g) and Intermediate 59 (8.96 g) to obtain the title compound (13.39 g).

출처 및 근거

ORD 기록
ord-cc24d669fdfd47959b83d7a2b71561b6
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07094789B2

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