Ammonia → 1-(4-Methoxybenzo[d]thiazol-2-yl)urea

HRID 1060289

반응식

HRID 1060289 반응식
[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[CH:9][CH:8]=[C:7]([O:11][CH3:12])[C:5]=2[N:6]=1.[NH2:13][C:14](N)=[O:15].N>O>[CH3:12][O:11][C:7]1[C:5]2[N:6]=[C:2]([NH:1][C:14]([NH2:13])=[O:15])[S:3][C:4]=2[CH:10]=[CH:9][CH:8]=1

참가 물질

5

반응물 3

HCID 222AmmoniaHCID 1176UreaHCID 216224-Methoxy-2-aminobenzothiazole

생성물 1

HCID 222830361-(4-Methoxybenzo[d]thiazol-2-yl)urea

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 2-amino-4-methoxy-benzothiazole (330 mg, 1.83 mmol) and urea (1.1 g, 1.83 mmol) were heated together for 1 h at 170° C., with evolution of ammonia. After allowing to cool to r.t., water (10 ml) was added and the mixture was vigorously stirred. The solid was then filtered, washed with water (10 ml) followed by ethanol (10 ml) and dried at 60° C. under vaccum (0.05 mmHg). The title product was afforded as an off-white solid (300 mg, 73% yield), MS: m/e=223 (M+).

후처리

  1. filtrationThe solid was then filtered
  2. washwashed with water (10 ml)
  3. customdried at 60° C. under vaccum (0.05 mmHg)

출처 및 근거

ORD 기록
ord-5e47205b13d14e91a5d9d364e4b842d7
출처 데이터셋
uspto-grants-2003_02
특허 번호
US06521754B2

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