Epibromohydrin → HCID 22640963, 화합물

HRID 1060381노트

반응식

HRID 1060381 반응식
[H-].[Na+].[C:3]([C@@H:5]1[CH2:10][CH2:9][CH2:8][CH2:7][C@H:6]1[OH:11])#[N:4].[CH2:12]([CH:14]1[O:16][CH2:15]1)Br>CN(C)C=O>[CH2:12]([O:11][CH:6]1[CH2:7][CH2:8][CH2:9][CH2:10][CH:5]1[C:3]#[N:4])[CH:14]1[O:16][CH2:15]1

참가 물질

5

반응물 3

HCID 18430EpibromohydrinHCID 24758Sodium hydrideHCID 2724649rac-(1R,2S)-2-hydroxycyclohexane-1-carbonitrile

생성물 1

HCID 22640963HCID 22640963, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Sodium hydride (60% suspension in mineral oil, 60 mg, 1.59 mmol) was added to a solution of trans-2-cyano-cyclohexanol in N,N-dimethylformamide (2.0 mL) and stirred for 10 minutes at room temperature. Epibromohydrin 0.22 g, 1.59 mmol) was then added and the reaction stirred for an additional 3 hours. The solution was partitioned between diethyl ether/water, and the layers separated. The ether layer was washed with water (3×100 mL) and dried over magnesium sulfate and evaporated to give 0.17 g of 2-cyanocyclohexyl glycidyl ether.

후처리

  1. stirringthe reaction stirred for an additional 3 hours
  2. customThe solution was partitioned between diethyl ether/water
  3. customthe layers separated
  4. washThe ether layer was washed with water (3×100 mL)
  5. dry with materialdried over magnesium sulfate
  6. customevaporated

출처 및 근거

ORD 기록
ord-dcf665f030be48b69dd7c3816a180876
출처 데이터셋
uspto-grants-2003_02
특허 번호
US06521667B1

반응 노트

불러오는 중…