Formaldehyde → 3-(Hydroxymethyl)-1H-pyrrole-2,5-dione

HRID 10604

반응식

HRID 10604 반응식
[C:1]1(=[O:7])[NH:5][C:4](=[O:6])[CH:3]=[CH:2]1.[CH2:8]=[O:9].[OH-].[Na+]>>[OH:9][CH2:8][C:2]1[C:1]([NH:5][C:4](=[O:6])[CH:3]=1)=[O:7]

참가 물질

4

반응물 3

HCID 712FormaldehydeHCID 10935MaleimideHCID 14798Sodium Hydroxide

생성물 1

HCID 219817513-(Hydroxymethyl)-1H-pyrrole-2,5-dione

실험 절차

24 Parts of maleimide (manufactured by Aldrich Corporation), 21 parts of 35% HCOH (manufactured by Wako Pure Chemical Industries, Ltd.) and 0.7 parts of a 5% aqueous NaOH solution are placed in a reactor and reacted at 40° C. for 2 hours. As a result, a white crystal of hydroxymethylmaleimide precipitates. This white crystal is filtered under reduced pressure and then dried at normal temperature under vacuum. The crude crystal of hydroxymethylmaleimide obtained in this manner is recrystallized from ethyl acetate to obtain 22 parts of hydroxymethylmaleimide.

후처리

  1. customreacted at 40° C. for 2 hours
  2. customAs a result, a white crystal of hydroxymethylmaleimide precipitates
  3. filtrationThis white crystal is filtered under reduced pressure
  4. customdried at normal temperature under vacuum

출처 및 근거

ORD 기록
ord-9a2925c670fe42288d32beb72b10d9f5
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07094860B2

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