Hydrogen Bromide → HCID 22992262, 화합물

HRID 1060635노트

반응식

HRID 1060635 반응식
[NH2:1][C:2]([C:10]1[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=1)([CH:4]1[CH2:9][CH2:8][O:7][CH2:6][CH2:5]1)N.Br>CCCCCCC>[NH2:1][CH:2]([C:10]1[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=1)[CH:4]1[CH2:5][CH2:6][O:7][CH2:8][CH2:9]1

참가 물질

4

반응물 2

HCID 260Hydrogen BromideHCID 22992265HCID 22992265, 화합물

생성물 1

HCID 22992262HCID 22992262, 화합물

시약·촉매·용매 1

HCID 8900Heptane용매

실험 절차

2.1.]heptane: Treatment of 1-amino-1-(3-pyridyl)-1-(4-tetrahydropyranyl)-methaneamine (576 mg, 3 mmol) with hydrobromic acid, as described for the synthesis of the 1-aza-2-(3-pyridyl)bicyclo[2.2.1]heptanes resulted in formation of the product, as a dark brown oil which was purified by column chromatography (15% methanol in chloroform), followed by distillation (90° C. at 0.005 mm Hg) under reduced pressure to obtain the product as a colorless oil (260 mg, 51% from 1-amino-1-(3 -pyridyl)-1-(4-tetrahydropyranyl)-methane.

후처리

  1. customresulted in formation of the product, as a dark brown oil which
  2. customwas purified by column chromatography (15% methanol in chloroform)
  3. distillationfollowed by distillation (90° C. at 0.005 mm Hg) under reduced pressure

출처 및 근거

ORD 기록
ord-0e0b1af67a834f3aa51954a9a22bc140
출처 데이터셋
uspto-grants-2003_02
특허 번호
US06525065B1

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