Water → Methyl [(2-oxobutyl)sulfanyl]acetate

HRID 1061664노트

반응식

HRID 1061664 반응식
C(N(CC)CC)C.[OH:8][CH:9]([CH2:17][CH3:18])[CH2:10][S:11][CH2:12][C:13]([O:15][CH3:16])=[O:14].O>CS(C)=O>[O:8]=[C:9]([CH2:17][CH3:18])[CH2:10][S:11][CH2:12][C:13]([O:15][CH3:16])=[O:14]

참가 물질

5

반응물 3

HCID 962WaterHCID 8471TriethylamineHCID 22284251Methyl 2-(2-hydroxybutylthio)acetate

생성물 1

HCID 12353742Methyl [(2-oxobutyl)sulfanyl]acetate

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

Triethylamine (28.3 ml) is added to a solution of methyl 2-(2-hydroxybutylthio)acetate (6.00 g, Reference compound No. 35-1) in dimethyl sulfoxide (180 ml). A sulfur trioxide-pyridine complex (20.0 g) is added to the mixture, and the whole is stirred for one hour. Water is added to the reaction mixture, and the whole is stirred for 20 minutes and extracted with ethyl acetate. The extract is washed with water, 1 N hydrochloric acid and saturated brine successively and dried over anhydrous magnesium sulfate. The extract is concentrated under reduced pressure, and the resulting residue is purified by silica gel column chromatography to give the titled reference compound (5.93 g).

후처리

  1. additionA sulfur trioxide-pyridine complex (20.0 g) is added to the mixture
  2. stirringthe whole is stirred for 20 minutes
  3. extractionextracted with ethyl acetate
  4. washThe extract is washed with water, 1 N hydrochloric acid and saturated brine successively
  5. dry with materialdried over anhydrous magnesium sulfate
  6. concentrationThe extract is concentrated under reduced pressure
  7. customthe resulting residue is purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-041cbb27fc20401c92b6a987c39cc489
출처 데이터셋
uspto-grants-2005_11
특허 번호
US06960575B2

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