Acetic Acid → tert-butyl 2-ethylhydrazinecarboxylate

HRID 1062326노트

반응식

HRID 1062326 반응식
[C:1]([O:5][C:6]([NH:8][N:9]=[CH:10][CH3:11])=[O:7])([CH3:4])([CH3:3])[CH3:2].C(O)(=O)C>C(O)C.O=[Pt]=O>[C:1]([O:5][C:6]([NH:8][NH:9][CH2:10][CH3:11])=[O:7])([CH3:4])([CH3:3])[CH3:2]

참가 물질

5

반응물 2

HCID 176Acetic AcidHCID 57358255tert-Butyl 2-ethylidenehydrazine-1-carboxylate

생성물 1

HCID 11194489tert-butyl 2-ethylhydrazinecarboxylate수율 97.5%

시약·촉매·용매 2

HCID 345198Adams' catalyst촉매HCID 702Ethanol용매

실험 절차

A slurry of N′-ethylidene-hydrazinecarboxylic acid tert-butyl ester (5.0 g, 32 mmol), acetic acid (48 μL) and PtO2 (250 mg) in ethanol (50 mL) was shaken under a 40 psi pressure of H2 in a Parr hydrogenator for 24 h. The mixture was filtered through Celite to provide N′-ethylhydrazinecarboxylic acid tert-butyl ester (5 g) as a clear oil. MS (ESI+) for C7H16N2O2 m/z 161.0 (M+H)+.

후처리

  1. filtrationThe mixture was filtered through Celite

출처 및 근거

ORD 기록
ord-846c360a658f4784b9fa1581d32e86d1
출처 데이터셋
uspto-grants-2005_11
특허 번호
US06960664B2

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