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4-Chloroaniline → HCID 178446836, 화합물

HRID 1062420
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HRID 1062420 반응식
[CH3:1][CH:2]([CH3:6])[CH2:3][C:4]#[N:5].[Al+3].[Cl-].[Cl-].[Cl-].[Cl:11][C:12]1[CH:18]=[CH:17][C:15]([NH2:16])=[CH:14][CH:13]=1>C1(C)C=CC=CC=1.O>[Cl:11][C:12]1[CH:18]=[CH:17][C:15]([NH:16][C:4](=[NH:5])[CH2:3][CH:2]([CH3:6])[CH3:1])=[CH:14][CH:13]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 78124-ChloroanilineHCID 12244IsovaleronitrileHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 178446836HCID 178446836, 화합물수율 58%

시약·촉매·용매 2

HCID 962Water용매HCID 1140Toluene용매

실험 절차

To a solution of 3-methylbutanenitrile (250 mg, 3.0 mmol) and AlCl3 (400 mg, 3.0 mmol) in toluene (6 mL) was added 4-chloroaniline (383 mg, 3.0 mmol). The resulting solution was stirred at reflux for 2 h, diluted with water, and extracted with EtOAc. The aqueous layer was neutralized with saturated NaHCO3 solution and extracted with EtOAc. The combined extracts were dried over MgSO4, filtered, and concentrated. The crude product (364 mg, 58% yield) was used for the next step without purification.

후처리

  1. temperatureat reflux for 2 h
  2. extractionextracted with EtOAc
  3. extractionextracted with EtOAc
  4. dry with materialThe combined extracts were dried over MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-e8724d6cb4a9438c9c3eeb94a9b9a95c
출처 데이터셋
uspto-grants-2005_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06960601B2

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