4-(t-Butoxycarbonyl)amino-2'-methylsulfonyl-[1,1']biphenyl → 4-(2-Methylsulfonylphenyl)aniline

HRID 1062656노트

반응식

HRID 1062656 반응식
C(OC([NH:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[S:21]([CH3:24])(=[O:23])=[O:22])=[CH:11][CH:10]=1)=O)(C)(C)C>Cl.O1CCOCC1>[NH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[S:21]([CH3:24])(=[O:23])=[O:22])=[CH:11][CH:10]=1

참가 물질

4

반응물 1

HCID 222825004-(t-Butoxycarbonyl)amino-2'-methylsulfonyl-[1,1']biphenyl

생성물 1

HCID 108005164-(2-Methylsulfonylphenyl)aniline수율 114.8%

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 312751,4-Dioxane용매

실험 절차

4-(t-butoxycarbonyl)amino-2′-methylsulfonyl-[1,1′]biphenyl (4.6 g, 13 mmol), was suspended in 100 mL of 4M HCl in dioxane and stirred 2.5 days. The resulting mixture was filtered and the cake rinsed with Et2O to yield a tan solid (3.69 g, 98%). 1H NMR (DMSO-d6) δ: 8.04 (d, 1H), 7.71 (t, 1H), 7.61 (t, 1H), 7.31 (m, 3H), 7.06 (m, 2H), 2.79 (s, 3H).

후처리

  1. filtrationThe resulting mixture was filtered
  2. washthe cake rinsed with Et2O

출처 및 근거

ORD 기록
ord-76430c068f6d4402a0da3177cbdce4f2
출처 데이터셋
uspto-grants-2005_11
특허 번호
US06962935B2

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