Ammonium Chloride → HCID 22281969, 화합물

HRID 1062804노트

반응식

HRID 1062804 반응식
C([O:4][CH2:5][CH2:6][O:7][C:8]1[C:12]([C:13]2[CH:21]=[CH:20][C:16]3[O:17][CH2:18][O:19][C:15]=3[CH:14]=2)=[C:11]([NH2:22])[N:10]([CH3:23])[N:9]=1)(=O)C.[Na].[Cl-].[NH4+]>C(O)C.O>[NH2:22][C:11]1[N:10]([CH3:23])[N:9]=[C:8]([O:7][CH2:6][CH2:5][OH:4])[C:12]=1[C:13]1[CH:21]=[CH:20][C:16]2[O:17][CH2:18][O:19][C:15]=2[CH:14]=1

참가 물질

6

반응물 3

HCID 25517Ammonium ChlorideHCID 5360545SodiumHCID 23400310HCID 23400310, 화합물

생성물 1

HCID 22281969HCID 22281969, 화합물수율 97.9%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

To a solution of 2-{[5-amino-4-(1,3-benzodioxol-5-yl)-1-methyl-1H-pyrazol-3-yl]oxy}ethyl acetate (100 mg) (Preparation 33) in ethanol (6 ml) at room temperature, was added sodium hydroxyde (100 mg). After one hour, the reaction was diluted with water (5 ml) and an aqueous saturated solution of ammonium chloride (10 ml). The mixture was extracted with ethyl acetate (3×6 ml). The organic fraction was dried over sodium sulfate and concentrated under reduced pressure to yield the title compound as a white solid (85 mg).

후처리

  1. extractionThe mixture was extracted with ethyl acetate (3×6 ml)
  2. dry with materialThe organic fraction was dried over sodium sulfate
  3. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-4810610c3e7a47a48a5fc640b37872ea
출처 데이터셋
uspto-grants-2005_11
특허 번호
US06962923B2

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