Dimethylsulphamoyl chloride → HCID 91272593, 화합물

반응식

[CH3:1][N:2]([CH3:7])[S:3](Cl)(=[O:5])=[O:4].[CH3:8][NH:9][CH:10]1[CH2:14][CH2:13][N:12]([C:15]([C:17]2[S:25][C:24]3[C:19](=[N:20][CH:21]=[CH:22][C:23]=3[Cl:26])[CH:18]=2)=[O:16])[CH2:11]1>>[CH3:8][N:9]([CH:10]1[CH2:14][CH2:13][N:12]([C:15]([C:17]2[S:25][C:24]3[C:19](=[N:20][CH:21]=[CH:22][C:23]=3[Cl:26])[CH:18]=2)=[O:16])[CH2:11]1)[S:3](=[O:5])(=[O:4])[N:2]([CH3:7])[CH3:1]

참가 물질

반응물 2

HCID 83372Dimethylsulphamoyl chloride

HCID 22278671HCID 22278671, 화합물

생성물 1

HCID 91272593HCID 91272593, 화합물

실험 절차

The title compound was prepared from dimethylsulfamoyl chloride and (3-methylamino-pyrrolidin-1-yl)-(7-chloro-thieno[3,2-b]pyridin-2yl)-methanone by a procedure analogous to Example 64C. MS: 403/405 (MH+); HPLC Rf: 4.76 min.; HPLC purity 98%.

출처 및 근거

ORD 기록: ord-aaa158f386c5429e840214c1132f433b
출처 데이터셋: uspto-grants-2005_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06964961B2

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