Bromomethylcyclopropane → HCID 69736387, 화합물

HRID 1063205노트

반응식

HRID 1063205 반응식
Br[CH2:2][CH:3]1[CH2:5][CH2:4]1.[OH:6][C@H:7]1[CH2:11][CH2:10][N:9]([C:12]([C:14]2[S:22][C:21]3[C:16](=[N:17][CH:18]=[CH:19][C:20]=3[Cl:23])[CH:15]=2)=[O:13])[CH2:8]1>>[Cl:23][C:20]1[CH:19]=[CH:18][N:17]=[C:16]2[CH:15]=[C:14]([C:12]([N:9]3[CH2:10][CH2:11][C@H:7]([O:6][CH2:2][CH:3]4[CH2:5][CH2:4]4)[CH2:8]3)=[O:13])[S:22][C:21]=12

참가 물질

3

반응물 2

HCID 81503BromomethylcyclopropaneHCID 23401166HCID 23401166, 화합물

생성물 1

HCID 69736387HCID 69736387, 화합물

실험 절차

The title compound was prepared from bromomethyl-cyclopropane and (3S)-(3-hydroxy-pyrrolidin-1-yl)-[7-chloro-thieno[3,2-b]pyridin-2-yl]-methanone by a procedure analogous to Example 67B. MS: 337.2/339.2 (MH+); HPLC Rf: 5.232 min.; 85%.

출처 및 근거

ORD 기록
ord-00c2827f60c94fb7b1eae8e56e2006c5
출처 데이터셋
uspto-grants-2005_11
특허 번호
US06964961B2

반응 노트

불러오는 중…