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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Sodium Hydroxide → 2-(6-amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-8-ylamino)ethylphosphonic acid

HRID 1063777
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인쇄 미리보기

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HRID 1063777 반응식
Br[C:2]1[N:3]([C:13]2[N:14]=[CH:15][N:16]=[C:17]([NH2:20])[C:18]=2[N:19]=1)[C@@H:4]1[O:12][C@H:9]([CH2:10][OH:11])[C@@H:7]([OH:8])[C@H:5]1[OH:6].[NH2:21][CH2:22][CH2:23][P:24](=[O:27])([O-:26])[O-:25].[OH-].[Na+]>C(O)C.O>[P:24]([CH2:23][CH2:22][NH:21][C:2]1[N:3]([C:13]2[N:14]=[CH:15][N:16]=[C:17]([NH2:20])[C:18]=2[N:19]=1)[C@@H:4]1[O:12][C@H:9]([CH2:10][OH:11])[C@@H:7]([OH:8])[C@H:5]1[OH:6])([OH:27])([OH:26])=[O:25]
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참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 965448-BromoadenosineHCID 23421211HCID 23421211, 화합물

생성물 1

HCID 445917212-(6-amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-8-ylamino)ethylphosphonic acid

시약·촉매·용매 1

HCID 19096565Water ethanol용매

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온도
110 °C

실험 절차

A mixture of 8-bromoadenosine (1 mmol), arninoethylphosphonate (2 mmol), and sodium hydroxide (2 mmol) in ethanol-water in a sealed tube was warmed at 110° C. under nitrogen. After 24 h the cooled reaction mixture was purified through preparative HPLC to give 8-(2-phosphonoethylamino)-adenosine (4.1). mp 175° C.; Anal. calcd. for C12H19N6O7P+0.5 H2O: C, 36.10; H, 5.05; N, 21.05; P, 7.76. Found: C, 36.08; H, 4.83; N, 20.36; P, 7.86.

후처리

  1. customAfter 24 h the cooled reaction mixture
  2. customwas purified through preparative HPLC

출처 및 근거

ORD 기록
ord-e7607e7b45bf4902aa72ae02d23ee5d2
출처 데이터셋
uspto-grants-2005_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06967193B1

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