Hydrochloric Acid → 2-(Piperidin-3-YL)acetonitrile
반응식
C(OC([N:11]1[CH2:16][CH2:15][CH2:14][CH:13]([CH2:17][C:18]#[N:19])[CH2:12]1)=O)C1C=CC=CC=1.Cl>C(O)C.[Pd]>[C:18]([CH2:17][CH:13]1[CH2:14][CH2:15][CH2:16][NH:11][CH2:12]1)#[N:19]참가 물질
5
실험 절차
1-Benzyloxycarbonyl-3-cyanomethylpiperidine (Method 22; 12.5 g) was dissolved in ethanol (20 ml) and ethereal HCl (1 ml) and 5% palladium on charcoal (2.0 g) was added. The mixture was shaken under an atmosphere of hydrogen for 2.5 hours. The catalst was filtered and the filtrate evaporated in vacuo. The crude product was dissolved in ethanol and recrystallized from ether. M/z 124 [M+].
후처리
- filtrationThe catalst was filtered
- customthe filtrate evaporated in vacuo
- dissolutionThe crude product was dissolved in ethanol
- customrecrystallized from ether
출처 및 근거
- ORD 기록
- ord-82858152ca03427e9c3f47032f249ff2
- 출처 데이터셋
- uspto-grants-2005_11
- 특허 번호
- US06967216B2
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