Hydrochloric Acid → 5-Isopropyl-4-[methyl-(1H-pyrrolo[2,3-b]pyridin-5-yl)-amino]-pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid methyl ester

반응식

[CH3:1][NH:2][C:3]1[CH:4]=[C:5]2[CH:11]=[CH:10][NH:9][C:6]2=[N:7][CH:8]=1.[CH3:12][O:13][C:14]([C:16]1[C:17]([CH:26]([CH3:28])[CH3:27])=[C:18]2[N:23]([CH:24]=1)[N:22]=[CH:21][N:20]=[C:19]2Cl)=[O:15].Cl>>[CH3:12][O:13][C:14]([C:16]1[C:17]([CH:26]([CH3:28])[CH3:27])=[C:18]2[N:23]([CH:24]=1)[N:22]=[CH:21][N:20]=[C:19]2[N:2]([CH3:1])[C:3]1[CH:4]=[C:5]2[CH:11]=[CH:10][NH:9][C:6]2=[N:7][CH:8]=1)=[O:15]

참가 물질

반응물 3

HCID 313Hydrochloric Acid

HCID 22273610N-methyl-1H-pyrrolo[2,3-b]pyridin-5-amine

HCID 866038554-Chloro-5-isopropylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid methyl ester

생성물 1

HCID 234035765-Isopropyl-4-[methyl-(1H-pyrrolo[2,3-b]pyridin-5-yl)-amino]-pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid methyl ester수율 25%

실험 절차

The title compound was prepared in a manner similar to the preparation of Example 24 by using methyl-(1H-pyrrolo[2,3-b]pyridin-5-yl)-amine and 4-chloro-5-isopropylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid methyl ester. (25% yield). LCMS; m/z 365 (M+H+). Monohydrochloride salt: 1H NMR (400 MHz, DMSO-d6) δ ppm 11.73 (1H, s), 8.22 (1H, s.), 8.00 (1H, s), 7.75 (1H, s), 7.50 (1H, s), 6.40 (1H, s.), 3.70 (3H, s), 3.26 (1H, m), 2.51 (3H, s), 0.54 (6H, d, J=7.3 Hz).