Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Fluorophenylboronic acid → 5-(2,2'-Difluorobiphenyl-5-yl)-3-(2,4-difluorophenyl)-[1,2,4]triazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Fluorophenylboronic acid | HCID 2734354 | — |
| 반응물 | 5-(3-Bromo-4-fluorophenyl)-3-(2,4-difluorophenyl)-[1,2,4]triazine | HCID 10384255 | — |
| 생성물 | 5-(2,2'-Difluorobiphenyl-5-yl)-3-(2,4-difluorophenyl)-[1,2,4]triazine | HCID 10339795 | — |
반응 단계
5-(3-Bromo-4-fluorophenyl)-3-(2,4-difluorophenyl)-[1,2,4]triazine was coupled to 2-fluorophenylboronic acid by the method of Example 12 to give 5-(2,2′-difluorobiphenyl-5-yl)-3-(2,4-difluorophenyl)-[1,2,4]triazine as a fluffy yellow solid: δH (400 MHz, CDCl3) 6.99-7.10 (2H, m), 7.21-7.23 (1H, m), 7.27-7.31 (1H, m), 7.37-7.48 (3H, m), 8.29-8.35 (3H, m), 9.64 (1H, s); m/z (ES+) 382.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06969716B2 |
| 출처 데이터셋 | uspto-grants-2005_11 |
| ORD ID | ord-d86419457e964098ba29ca1f430548b3 |
| 출처 메모 | uspto-grants-2005_11 |