5-(3-Bromo-4-fluorophenyl)-3-(2,4-difluorophenyl)-[1,2,4]triazine → 3,2'-Difluoro-5'-[3-(2,4-difluorophenyl)-[1,2,4]triazin-5-yl]biphenyl-2-carbonitrile

참여 물질

역할	이름	HCID	투입량
반응물	5-(3-Bromo-4-fluorophenyl)-3-(2,4-difluorophenyl)-[1,2,4]triazine	HCID 10384255	—
반응물	2-Cyano-3-fluorophenylboronic acid pinacol ester	HCID 22273603	—
생성물	3,2'-Difluoro-5'-[3-(2,4-difluorophenyl)-[1,2,4]triazin-5-yl]biphenyl-2-carbonitrile	HCID 10092721	—

반응 단계

5-(3-Bromo-4-fluorophenyl)-3-(2,4-difluorophenyl)-[1,2,4]triazine was coupled to 6-fluoro-2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzonitrile by the method of Example 12 to give 3,2′-difluoro-5′-[3-(2,4-difluorophenyl)-[1,2,4]triazin-5-yl]biphenyl-2-carbonitrile as a yellow solid: δH (400 MHz, CDCl3) 6.99-7.11 (2H, m), 7.32-7.40 (2H, m), 7.47 (1H, t, J 9.2 Hz), 7.70-7.76 (1H, m), 8.30-8.40 (3H, m), 9.66 (1H, s); m/z(ES+) 407.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US06969716B2
출처 데이터셋	uspto-grants-2005_11
ORD ID	ord-6b6bae67751f45b0911a416d109b5fdd
출처 메모	uspto-grants-2005_11