反应详情

5-(3-Bromo-4-fluorophenyl)-3-(2,4-difluorophenyl)-[1,2,4]triazine was coupled to 6-fluoro-2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzonitrile by the method of Example 12 to give 3,2′-difluoro-5′-[3-(2,4-difluorophenyl)-[1,2,4]triazin-5-yl]biphenyl-2-carbonitrile as a yellow solid: δH (400 MHz, CDCl3) 6.99-7.11 (2H, m), 7.32-7.40 (2H, m), 7.47 (1H, t, J 9.2 Hz), 7.70-7.76 (1H, m), 8.30-8.40 (3H, m), 9.66 (1H, s); m/z(ES+) 407.