Sodium Hydroxide → 2-[4-(2-aminoethyl)piperazin-1-yl]ethanol

HRID 1064818노트

반응식

HRID 1064818 반응식
[C:1]([CH2:3][N:4]1[CH2:9][CH2:8][N:7]([CH2:10][CH2:11][OH:12])[CH2:6][CH2:5]1)#[N:2].[H-].[Al+3].[Li+].[H-].[H-].[H-].[OH-].[Na+]>C1COCC1.C(O)C>[NH2:2][CH2:1][CH2:3][N:4]1[CH2:9][CH2:8][N:7]([CH2:10][CH2:11][OH:12])[CH2:6][CH2:5]1

참가 물질

6

반응물 3

HCID 14798Sodium HydroxideHCID 21226445Aluminium lithium hydrideHCID 22272590HCID 22272590, 화합물

생성물 1

HCID 47424572-[4-(2-aminoethyl)piperazin-1-yl]ethanol

시약·촉매·용매 2

HCID 702Ethanol용매HCID 8028Tetrahydrofuran용매2회

실험 절차

A solution of 4-(cyanomethyl)piperazine-1-ethanol (1.69 g, 10 mmol) in THF (20 ml) was added to a solution of lithium aluminum hydride in THF (20 ml, 20 mmol) in an argon stream with ice cooling, the mixture was stirred at room temperature for 5 minutes and heated to reflux for 90 minutes. The reaction solution was allowed to cool, diluted with ethanol with ice cooling and stirred at room temperature for 15 minutes after adding an aqueous 1N sodium hydroxide solution thereto. This was filtered off through celite and the filtrate was concentrated in vacuo to provide 4-(aminoethyl)piperazine-1-ethanol.

후처리

  1. temperatureheated
  2. temperatureto reflux for 90 minutes
  3. temperatureto cool
  4. stirringstirred at room temperature for 15 minutes
  5. filtrationThis was filtered off through celite
  6. concentrationthe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-539c88751648429f939d960524738f57
출처 데이터셋
uspto-grants-2005_11
특허 번호
US06969711B2

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