Sulfuric Acid → 4-(Benzyloxy)-1-bromo-2-fluorobenzene

반응식

[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:3]=1.[Br:16]N1C(=O)CCC1=O.S(=O)(=O)(O)O>>[Br:16][C:7]1[CH:6]=[CH:5][C:4]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:3][C:2]=1[F:1]

참가 물질

반응물 3

HCID 1118Sulfuric Acid

HCID 67184N-bromobutanimide

HCID 116298011-(Benzyloxy)-3-fluorobenzene2회

생성물 1

HCID 222739334-(Benzyloxy)-1-bromo-2-fluorobenzene

실험 절차

In analogy to the procedure described in example 8 b], 1-fluoro-3-(phenylmethoxy)-benzene (for the preparation of 1-fluoro-3-(phenylmethoxy)-benzene see: A. A. Durrani, J. H. P. Tyman, J. Chem. Soc., Perkin Trans. 1 1979, 8, 2079-2087) was treated with N-bromosuccinimide in the presence of concentrated sulfuric acid to give 1-bromo-2-fluoro-4-(phenylmethoxy)-benzene as colorless oil.

출처 및 근거

ORD 기록: ord-8bd00730a5fb494a8abc8748a52453f7
출처 데이터셋: uspto-grants-2005_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06969725B2

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