Dimethylformamide → 4-Benzyloxy-2-(trifluoromethyl)benzaldehyde

HRID 1064948

반응식

HRID 1064948 반응식
Br[C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:4][C:3]=1[C:16]([F:19])([F:18])[F:17].[Li]CCCC.CN(C)[CH:27]=[O:28]>O1CCCC1>[CH2:9]([O:8][C:5]1[CH:6]=[CH:7][C:2]([CH:27]=[O:28])=[C:3]([C:16]([F:19])([F:18])[F:17])[CH:4]=1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 222738644-(Benzyloxy)-1-bromo-2-(trifluoromethyl)benzeneHCID 178418339Butyllithium

생성물 1

HCID 222738854-Benzyloxy-2-(trifluoromethyl)benzaldehyde

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

In analogy to the procedure described in example 8 c], 1-bromo-2-trifluoromethyl-4-(phenylmethoxy)-benzene was treated with n-BuLi and N,N-dimethylformamide in dry tetrahydrofuran to yield 4-benzyloxy-2-trifluoromethyl-benzaldehyde as colorless liquid.

출처 및 근거

ORD 기록
ord-bc3bf74a827e44eba5c73ae78aa96eb5
출처 데이터셋
uspto-grants-2005_11
특허 번호
US06969725B2

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