Sodium Hydroxide → HCID 20540294, 화합물

HRID 1065308노트

반응식

HRID 1065308 반응식
[OH-].[Na+].[C:3]([OH:7])(=[S:6])[CH2:4][CH3:5].[C:8]([NH:11][C:12](=[O:15])[CH2:13]Cl)(=[O:10])[CH3:9]>O>[C:8]([NH:11][C:12](=[O:15])[CH2:13][S:6][C:3](=[O:7])[CH2:4][CH3:5])(=[O:10])[CH3:9]

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 2366697N-acetyl-2-chloroacetamideHCID 178460587HCID 178460587, 화합물

생성물 1

HCID 20540294HCID 20540294, 화합물

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

To a solution of 4.0 g. (0.1 mole) of sodium hydroxide in 50 ml. of water, cooled in ice and having nitrogen bubbled therethrough, was added 9.5 g. (0.1 mole) of thiopropionic acid. The reaction mixture was stirred for 5 minutes, after which there was added 13.7 g. of N-acetyl-chloroacetamide in 50 ml. of water. The reaction mixture was heated on a steam bath for 10 minutes, then cooled, filtered, and air dried. The product was washed with ether/hexane (3:1) three times with 150 ml. each washing, and then air dried. The product was recrystallized from water to yield 8.0 g. of white crystals.

후처리

  1. custombubbled
  2. additionwas added 9.5 g
  3. additionafter which there was added 13.7 g
  4. temperatureThe reaction mixture was heated on a steam bath for 10 minutes
  5. temperaturecooled
  6. filtrationfiltered
  7. customair dried
  8. washThe product was washed with ether/hexane (3:1) three times with 150 ml
  9. customeach washing, and then air dried
  10. customThe product was recrystallized from water
  11. customto yield 8.0 g

출처 및 근거

ORD 기록
ord-f236a1bdb66f41a9b1ed1ca4c314168f
출처 데이터셋
uspto-grants-1982_05
특허 번호
US04329363

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