Acetone → 2,4-diaminophenyl gamma-N,N-dimethylaminopropyl ether trihydrochloride

반응식

[CH3:1][N:2]([CH2:4][CH2:5][CH2:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([NH2:14])=[CH:10][C:9]=1[NH:15]C(=O)C)[CH3:3].CC(C)=O.[ClH:23]>>[ClH:23].[ClH:23].[ClH:23].[CH3:1][N:2]([CH2:4][CH2:5][CH2:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([NH2:14])=[CH:10][C:9]=1[NH2:15])[CH3:3]

참가 물질

반응물 3

HCID 180Acetone

HCID 313Hydrochloric Acid

HCID 205387972-acetylamino-4-aminophenyl gammaN,N-dimethylaminopropyl ether

생성물 1

HCID 203270292,4-diaminophenyl gamma-N,N-dimethylaminopropyl ether trihydrochloride

실험 절차

57 g of 2-acetylamino-4-aminophenyl γN,N-dimethylaminopropyl ether in 112 ml of hydrochloric acid (d=1.19) are heated for 75 minutes in a boiling water bath. The reaction medium is cooled and 75 ml of acetone are then added. The expected product precipitates in the form of the trihydrochloride, which melts at 236° C. with decomposition.

후처리

temperatureThe reaction medium is cooled
customThe expected product precipitates in the form of the trihydrochloride, which melts at 236° C. with decomposition

출처 및 근거

ORD 기록: ord-000f8b0c58be4a4c95e623698d772808
출처 데이터셋: uspto-grants-1982_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04330292

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