Dimethyl Sulfate → Benzamide, 4-chloro-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-(methyl(methylsulfonyl)amino)-

HRID 1065617노트

반응식

HRID 1065617 반응식
[CH2:1]([N:3]1[CH2:7][CH2:6][CH2:5][CH:4]1[CH2:8][NH:9][C:10](=[O:25])[C:11]1[CH:16]=[C:15]([NH:17][S:18]([CH3:21])(=[O:20])=[O:19])[C:14]([Cl:22])=[CH:13][C:12]=1[O:23][CH3:24])[CH3:2].S(OC)(O[CH3:30])(=O)=O>>[CH2:1]([N:3]1[CH2:7][CH2:6][CH2:5][CH:4]1[CH2:8][NH:9][C:10](=[O:25])[C:11]1[CH:16]=[C:15]([N:17]([CH3:30])[S:18]([CH3:21])(=[O:20])=[O:19])[C:14]([Cl:22])=[CH:13][C:12]=1[O:23][CH3:24])[CH3:2]

참가 물질

3

반응물 2

HCID 6497Dimethyl SulfateHCID 3051978Benzamide, 4-chloro-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-((methylsulfonyl)amino)-

생성물 1

HCID 3051973Benzamide, 4-chloro-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-(methyl(methylsulfonyl)amino)-

실험 절차

Using N-(1-ethyl-2-pyrrolidinylmethyl)-2-methoxy-4-chloro-5-methanesulfonamidobenzamide and dimethyl sulfate, the reaction is effected as in Example 5, whereby N-(1-ethyl-2-pyrrolidinylmethyl)-2-methoxy-4-chloro-5-(N-methylmethanesulfonamido)benzamide is obtained as crystals melting at 140.5° to 142° C.

출처 및 근거

ORD 기록
ord-cf57e62767894a3b9383886e6ab8df01
출처 데이터셋
uspto-grants-1982_05
특허 번호
US04330472

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