Sodium Hydroxide → 2-Methoxyimino-2-(3-chloro-4-hydroxyphenyl)acetic acid

HRID 1065876노트

반응식

[CH3:1][O:2][N:3]=[C:4]([C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[C:11]([Cl:16])[CH:10]=1)[C:5]([O:7]C)=[O:6].[OH-].[Na+]>>[CH3:1][O:2][N:3]=[C:4]([C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[C:11]([Cl:16])[CH:10]=1)[C:5]([OH:7])=[O:6]

참가 물질

반응물 2

HCID 14798Sodium Hydroxide

HCID 136176295Methyl 2-methoxyimino-2-(3-chloro-4-hydroxyphenyl)acetate

생성물 1

HCID 1360939502-Methoxyimino-2-(3-chloro-4-hydroxyphenyl)acetic acid수율 97.9%

실험 절차

Methyl 2-methoxyimino-2-(3-chloro-4-hydroxyphenyl)acetate (syn isomer) (2.6 g.) and a 2 N aqueous solution of sodium hydroxide (10.6 ml.) were treated according to a similar manner to that of Preparation 5-3)(c) to give 2-methoxyimino-2-(3-chloro-4-hydroxyphenyl)acetic acid (syn isomer) (2.4 g.), mp 147° to 150° C. (dec.).

후처리

customof Preparation 5-3)(c)

출처 및 근거

ORD 기록: ord-cd9ab45a65b24466b27e15c91e2f7868
출처 데이터셋: uspto-grants-1982_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04331664

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