Hydrochloric Acid → HCID 20573874, 화합물

HRID 1065961

반응식

HRID 1065961 반응식
C[O:2][C:3]1[CH:10]=[C:9](OC)[C:6]([CH:7]=O)=[C:5]([OH:13])[CH:4]=1.[CH3:14][C:15]([C:17]1[CH:22]=[CH:21][C:20]([O:23]C)=[CH:19][CH:18]=1)=[O:16].[ClH:25]>CCOCC>[CH:18]1[C:17]([C:15]2[CH:14]=[CH:7][C:6]3[C:5]([OH:13])=[CH:4][C:3]([OH:2])=[CH:10][C:9]=3[O+:16]=2)=[CH:22][CH:21]=[C:20]([OH:23])[CH:19]=1.[Cl-:25].[Cl-:25]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 74764'-MethoxyacetophenoneHCID 697254,6-Dimethoxysalicylaldehyde

생성물 1

HCID 20573874HCID 20573874, 화합물

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

One method consists, for example, in preparing, in a first step, trimethylapigenidin by condensation of commercially available 4,6-dimethoxy-2-hydroxybenzaldehyde with commercially available 4-methoxyacetophenone at 0° C. in anhydrous ether medium, and saturation with anhydrous HCl in order to obtain, after filtration, an orange-red precipitate of trimethylapigenidin. In a second step, in hydrolysing the trimethylapigenidin obtained in the preceding step to apigenidin chloride, the reaction being carried out in an HI and phenol and AgCl medium in solution in methanol. Such a method of synthesis is described by R. Robinson and A. Robertson in J., Chem., Soc. 1951-(1926) and 2196-(1927).

후처리

  1. customto obtain
  2. filtrationafter filtration

출처 및 근거

ORD 기록
ord-950eaab79849496da2cb9d7fe7039fdb
출처 데이터셋
uspto-grants-2001_06
특허 번호
US06241785B1

연결된 노트

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