Hydrochloric Acid → 2-Propanol, 1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-, hydrochloride, (S)-

HRID 1066011

반응식

HRID 1066011 반응식
[ClH:1].[CH3:2][C:3]([NH:6][CH2:7][C@H:8]([OH:22])[CH2:9][O:10][C:11]1[C:12]([N:16]2[CH2:21][CH2:20][O:19][CH2:18][CH2:17]2)=[N:13][S:14][N:15]=1)([CH3:5])[CH3:4]>C(O)(C)C>[ClH:1].[CH3:5][C:3]([NH:6][CH2:7][C@H:8]([OH:22])[CH2:9][O:10][C:11]1[C:12]([N:16]2[CH2:21][CH2:20][O:19][CH2:18][CH2:17]2)=[N:13][S:14][N:15]=1)([CH3:2])[CH3:4]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 33624Timolol

생성물 1

HCID 1552082-Propanol, 1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-, hydrochloride, (S)-수율 91%

시약·촉매·용매 1

HCID 3776Isopropanol용매2회

실험 절차

0.8 ml of a 7M HCl solution in isopropanol was added dropwise to a magnetically stirred solution of timolol (1.4 g) in isopropanol (30 ml). The solution was stirred for 30 minutes. The reaction mixture was freed of the solvent at reduced pressure. 1.47 g of pure product was obtained (yield 91%).

출처 및 근거

ORD 기록
ord-4441b34afb6240a7bee27d9b58d30fb9
출처 데이터셋
uspto-grants-2001_06
특허 번호
US06242432B1

연결된 노트

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