Hydrochloric Acid → Zolpidem hydrochloride

HRID 1066184

반응식

HRID 1066184 반응식
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:16]=[C:15]3[N:10]([CH:11]=[C:12]([CH3:17])[CH:13]=[CH:14]3)[C:9]=2[CH2:18][C:19]([N:21]([CH3:23])[CH3:22])=[O:20])=[CH:6][CH:7]=1.[ClH:24]>C(O)C>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:16]=[C:15]3[N:10]([CH:11]=[C:12]([CH3:17])[CH:13]=[CH:14]3)[C:9]=2[CH2:18][C:19]([N:21]([CH3:22])[CH3:23])=[O:20])=[CH:4][CH:3]=1.[ClH:24]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 5732Zolpidem

생성물 1

HCID 18004031Zolpidem hydrochloride

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
50 °C

실험 절차

Zolpidem free base (1.0 g) is suspended in 10 ml of ethanol and heated at 50° C. until dissolution. Then, 0.32 g (molar equivalent) of concentrated hydrochloric acid is added and the solution stirred for 10 minutes. Then the bath is removed and the reaction mixture is allowed to cool to room temperature. Finally, the mixture is kept standing overnight at 4° C. The formed crystals are filtered off, washed with 3 ml of cold ethanol and dried at 40° C. in a vacuum oven to produce zolpidem hydrochloride hemiethanolate.

후처리

  1. customThen the bath is removed
  2. temperatureto cool to room temperature
  3. waitFinally, the mixture is kept standing overnight at 4° C
  4. filtrationThe formed crystals are filtered off
  5. washwashed with 3 ml of cold ethanol
  6. customdried at 40° C. in a vacuum oven

출처 및 근거

ORD 기록
ord-b0b0e4102bd547e1a655f8aeafa12160
출처 데이터셋
uspto-grants-2001_06
특허 번호
US06242460B1

연결된 노트

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