Hydrochloric Acid → 2-chloro-N-(5-methoxy-2-methylphenyl)acetamide

HRID 1066261

반응식

HRID 1066261 반응식
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH3:10])=[C:7]([CH:9]=1)[NH2:8].C(N(CC)CC)C.[Cl:18][CH2:19][C:20](Cl)=[O:21].Cl>ClCCl>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH3:10])=[C:7]([NH:8][C:20](=[O:21])[CH2:19][Cl:18])[CH:9]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 6577Chloroacetyl chlorideHCID 8471TriethylamineHCID 995005-Methoxy-o-toluidine

생성물 1

HCID 11328892-chloro-N-(5-methoxy-2-methylphenyl)acetamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 5-methoxy-2-methylaniline (7.62 g) and triethylamine (15.5 ml) in dichloromethane (150 ml) at 0-5° C. was added chloroacetyl chloride (5.0 ml) dropwise and the ice bath removed. The resulting reaction mixture was stirred for 45 min before being poured into dil HCl and extracted with dichloromethane. Organic extracts were combined, washed with water, dried (Na2SO4) and concentrated to give a brown solid that was triturated with diethyl ether to leave the sub-title compound as a beige solid (5.7 g).

후처리

  1. customthe ice bath removed
  2. customThe resulting reaction mixture
  3. extractionextracted with dichloromethane
  4. washwashed with water
  5. dry with materialdried (Na2SO4)
  6. concentrationconcentrated
  7. customto give a brown solid that
  8. customwas triturated with diethyl ether

출처 및 근거

ORD 기록
ord-dfa0a48bffc6424384cdfa0f59d777dd
출처 데이터셋
uspto-grants-2001_06
특허 번호
US06242470B1

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