Triethylamine → HCID 17909256, 화합물

HRID 1067176

반응식

HRID 1067176 반응식
[CH2:1]([O:8][C:9]([NH:11][CH2:12][CH2:13][NH:14][CH2:15][CH2:16][NH:17][C:18]([O:20][CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[O:19])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C([N:30]([CH2:33][CH3:34])[CH2:31][CH3:32])C.[N+:35]([C:38]1[CH:39]=[C:40]([C:47](Cl)=[O:48])[CH:41]=[C:42]([CH:46]=1)[C:43](Cl)=[O:44])([O-:37])=[O:36]>CN(C)C=O>[CH2:1]([O:8][C:9]([NH:11][CH2:12][CH2:13][N:14]([CH2:15][CH2:16][NH:17][C:18]([O:20][CH2:21][C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1)=[O:19])[C:47](=[O:48])[C:40]1[CH:39]=[C:38]([N+:35]([O-:37])=[O:36])[CH:46]=[C:42]([C:43]([N:30]([CH2:31][CH2:32][NH:11][C:9]([O:8][CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[O:10])[CH2:33][CH2:34][NH:17][C:18]([O:20][CH2:21][C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)=[O:19])=[O:44])[CH:41]=1)=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 834515-Nitroisophthaloyl chlorideHCID 4367374N,N''-Di-Z-diethylenetriamine

생성물 1

HCID 17909256HCID 17909256, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

14.86 g (40 mmol) of the bis[2-(benzyloxycarbonylamino)-ethyl]-amine described in Example 1a and 20.24 g (200 mmol) of triethylamine are dissolved in dimethylformamide and mixed with 4.96 g (20 mmol) of 5-nitro-isophthalic acid dichloride (J. Chem. Soc. 1957, 1172-1175) and stirred overnight at room temperature. The solution is concentrated by evaporation in a vacuum and the residue is chromatographed with ethyl acetate on silica gel.

후처리

  1. concentrationThe solution is concentrated by evaporation in a vacuum
  2. customthe residue is chromatographed with ethyl acetate on silica gel

출처 및 근거

ORD 기록
ord-51fe1b4e2e1f42c685f7064504a78e2b
출처 데이터셋
uspto-grants-2001_06
특허 번호
US06248306B1

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