Sodium borohydride → (1-Chloroisoquinolin-5-yl)methanol
반응식
[Cl:1][C:2]1[C:11]2[CH:10]=[CH:9][CH:8]=[C:7]([CH:12]=[O:13])[C:6]=2[CH:5]=[CH:4][N:3]=1.[BH4-].[Na+]>CO>[Cl:1][C:2]1[C:11]2[C:6](=[C:7]([CH2:12][OH:13])[CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][N:3]=1참가 물질
4
실험 절차
A solution of 1-chloro-5-isoquinolinecarboxaldehyde (308 mg, 1.6 mmol) and sodium borohydride (NaBH4) (68 mg, 1.8 mmol) in MeOH (6 mL) was stirred at room temperature for 2 h. The reaction was quenched with water (2 mL) and concentrated in vacuo. The residue was suspended in CH2Cl2, washed with water, with brine and then dried over MgSO4 and evaporated. The residue was purified by column chromatography upon silica gel using hexanes-EtOAc (80:20 to 50:50) as eluant to give 1-chloro-5-(hydroxymethyl)isoquinoline (240 mg, 1.23 mmol) as a white solid.
후처리
- customThe reaction was quenched with water (2 mL)
- concentrationconcentrated in vacuo
- washwashed with water, with brine
- dry with materialdried over MgSO4
- customevaporated
- customThe residue was purified by column chromatography upon silica gel
출처 및 근거
- ORD 기록
- ord-b3d412980bae4d8eaeeb27c270d38927
- 출처 데이터셋
- uspto-grants-2001_06
- 특허 번호
- US06248738B1
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