Phenylacetonitrile → 2-Phenylethanethioamide

HRID 1067416

반응식

HRID 1067416 반응식
[C:1]1([CH2:7][C:8]#[N:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.P([O-])(OCC)(SCC)=[S:11]>Cl.C(OCC)(=O)C>[C:1]1([CH2:7][C:8]([NH2:9])=[S:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

4

반응물 2

HCID 8794PhenylacetonitrileHCID 53249491Diethyldithiophosphate

생성물 1

HCID 7313682-Phenylethanethioamide수율 55%

시약·촉매·용매 1

HCID 21866389Hydrogen chloride-ethyl acetate용매

실험 절차

A solution of phenylacetonitrile (10.0 g, 85.4 mmol) and diethyl dithiophosphate (17.5 g, 93.9 mmol) in 4N-HCl/ethyl acetate (400 mL) was stirred at room temperature for 16 hours. This reaction mixture was washed with water and saturated aqueous sodium hydrogen carbonate solution, dried over MgSO4, filtered, and concentrated under reduced pressure. The residue was crystallized from ethanol to provide 7.1 g of the title compound. Yield 55%.

후처리

  1. washThis reaction mixture was washed with water and saturated aqueous sodium hydrogen carbonate solution
  2. dry with materialdried over MgSO4
  3. filtrationfiltered
  4. concentrationconcentrated under reduced pressure
  5. customThe residue was crystallized from ethanol

출처 및 근거

ORD 기록
ord-b95e9b3ac9114e76baa3b07b56de8fcd
출처 데이터셋
uspto-grants-2001_06
특허 번호
US06248766B1

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