Dimethylformamide → Ethyl 6-[3-[4-(Diphenylmethoxy)piperidino]propylamino]imidazo[1,2-b]pyridazine-2-carboxylate Difumarate

HRID 1067523노트

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HRID 1067523 반응식
[C:1]1([CH:7]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[O:8][CH:9]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][NH2:18])[CH2:11][CH2:10]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl[C:26]1[CH:27]=[CH:28][C:29]2[N:30]([CH:32]=[C:33]([C:35]([O:37][CH2:38][CH3:39])=[O:36])[N:34]=2)[N:31]=1.C(N(C(C)C)C(C)C)C.CN(C)[CH:51]=[O:52]>>[C:9]([OH:8])(=[O:52])/[CH:32]=[CH:33]/[C:35]([OH:37])=[O:36].[C:51]([OH:52])(=[O:8])/[CH:32]=[CH:33]/[C:35]([OH:37])=[O:36].[C:19]1([CH:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[O:8][CH:9]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][NH:18][C:26]3[CH:27]=[CH:28][C:29]4[N:30]([CH:32]=[C:33]([C:35]([O:37][CH2:38][CH3:39])=[O:36])[N:34]=4)[N:31]=3)[CH2:11][CH2:10]2)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

참가 물질

5

반응물 4

HCID 6228DimethylformamideHCID 81531DiisopropylethylamineHCID 2779714ethyl 6-chloroimidazo[1,2-b]pyridazine-2-carboxylateHCID 109693934-(Diphenylmethoxy)-1-piperidinepropaneamine

생성물 1

HCID 69843796Ethyl 6-[3-[4-(Diphenylmethoxy)piperidino]propylamino]imidazo[1,2-b]pyridazine-2-carboxylate Difumarate

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온도
80 °C

실험 절차

686 mg of 4-(diphenylmethoxy)-1-piperidinepropanamine and 477 mg of ethyl 6-chloroimidazo[1,2-b]pyridazin-2-carboxylate were dissolved in 7 ml of N,N-dimethylformamide; 0.73 ml of N-ethyldiisopropylamine was added, followed by stirring in an oil bath (80° C.) for 18.5 hours. After cooling, ice water and saline were added, followed by extraction with ethyl acetate-tetrahydrofuran (1:1); the extract was washed with saturated saline and dried with magnesium sulfate. The dry product was concentrated under reduced pressure; the residue was subjected to silica gel column chromatography and eluted with ethyl acetate:methanol:triethylamine (50:5:1). The desired fraction was collected, dissolved in 5 ml of ethyl acetate; a solution of 95 mg of fumaric acid in 5 ml of ethanol was added, followed by concentration. Acetone-ethyl ether (1:2) was added to the residue to cause recrystallization; the crystal precipitate was collected by filtration and washed with ethyl ether to yield 211 mg of the title compound.

후처리

  1. temperatureAfter cooling
  2. extractionfollowed by extraction with ethyl acetate-tetrahydrofuran (1:1)
  3. washthe extract was washed with saturated saline
  4. dry with materialdried with magnesium sulfate
  5. concentrationThe dry product was concentrated under reduced pressure
  6. washeluted with ethyl acetate:methanol:triethylamine (50:5:1)
  7. customThe desired fraction was collected
  8. dissolutiondissolved in 5 ml of ethyl acetate
  9. additiona solution of 95 mg of fumaric acid in 5 ml of ethanol was added
  10. concentrationfollowed by concentration
  11. additionAcetone-ethyl ether (1:2) was added to the residue
  12. customrecrystallization
  13. filtrationthe crystal precipitate was collected by filtration
  14. washwashed with ethyl ether

출처 및 근거

ORD 기록
ord-fa3f0acf4aad47a380bac183c5d8e58c
출처 데이터셋
uspto-grants-2001_06
특허 번호
US06248740B1

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