Pyridine → 2-Methyl-2-adamantyl methacrylate

HRID 1068064

반응식

HRID 1068064 반응식
N1C=CC=CC=1.[CH3:7][C:8]1([OH:18])[CH:15]2[CH2:16][CH:11]3[CH2:12][CH:13]([CH2:17][CH:9]1[CH2:10]3)[CH2:14]2.[C:19](Cl)(=[O:23])[C:20]([CH3:22])=[CH2:21]>C1COCC1>[C:19]([O:18][C:8]1([CH3:7])[CH:9]2[CH2:17][CH:13]3[CH2:12][CH:11]([CH2:16][CH:15]1[CH2:14]3)[CH2:10]2)(=[O:23])[C:20]([CH3:22])=[CH2:21]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 13528Methacryloyl chlorideHCID 1365452-Methyl-2-adamantanol

생성물 1

HCID 98375662-Methyl-2-adamantyl methacrylate수율 39%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

The procedure of Comparative Example 1 was repeated with the proviso that under the cooling conditions, 24 ml of pyridine was slowly dropwise added to a mixture of 22.6 g (0.136 mole) of 2-methyl-2-adamantanol, 130 ml of THF and 26.6 g of methacrylic chloride. The raw product was purified on a column of silica gel to obtain 12.1 g of the target product, i.e., 2-methyl-2-adamantyl methacrylate, (yield: 39.0%). It was confirmed that the product contained a remarkable amount of impurities.

후처리

  1. customThe raw product was purified on a column of silica gel

출처 및 근거

ORD 기록
ord-10c5f114a4514394bddbfc4b522f2321
출처 데이터셋
uspto-grants-2001_06
특허 번호
US06248920B1

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