Ammonium formate → 2-Methyl-1-(4-piperidinyl)-1H-benzimidazole
반응식
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=3[N:16]=[C:15]2[CH3:23])[CH2:10][CH2:9]1)C1C=CC=CC=1.C([O-])=O.[NH4+]>[Pd].CO>[NH:8]1[CH2:9][CH2:10][CH:11]([N:14]2[C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=3[N:16]=[C:15]2[CH3:23])[CH2:12][CH2:13]1참가 물질
5
실험 절차
The title compound was prepared from 120 mg of 1-(1-benzyl-piperidin-4-yl)-1-H-benzoimidazole (from Step A), 100 mg of 10% palladium on carbon and 100 mg of ammonium formate in 5 mL of MeOH using a procedure analogous to that described in Example 95, Step C to provide 70 mg of the title compound as a solid.
출처 및 근거
- ORD 기록
- ord-dbb3309f6fc242769d150afed727b9b1
- 출처 데이터셋
- uspto-grants-2001_06
- 특허 번호
- US06248755B1
반응 노트
불러오는 중…