Ammonium formate → 4-(4-Benzyltriazol-2-yl)piperidine

HRID 1068172노트

반응식

HRID 1068172 반응식
[CH2:1]([C:8]1[CH:12]=[N:11][N:10]([CH:13]2[CH2:18][CH2:17][N:16](CC3C=CC=CC=3)[CH2:15][CH2:14]2)[N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C([O-])=O.[NH4+]>[Pd].CO>[CH2:1]([C:8]1[CH:12]=[N:11][N:10]([CH:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)[N:9]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 2

HCID 2723923Ammonium formateHCID 211931244-(4-Benzyltriazol-2-yl)-1-benzylpiperidine

생성물 1

HCID 211930964-(4-Benzyltriazol-2-yl)piperidine수율 9%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A mixture of 4-(4-benzyltriazol-2-yl)-1-benzylpiperidine (627 mg, 1.9 mmol, from Step B), 10% palladium on carbon (400 mg, 0.38 mmol) and ammonium formate (770 mg, 11.3 mmol) in 20 mL MeOH was refluxed for 1 h. The mixture was filtered through celite and concentrated. The residue was dissolved in chloroform and the solution was washed with 1M aqueous NaOH. The organic layer was dried over Na2SO4 and concentrated to afford 41 mg (9%) of product was obtained which was used in the next step without purification.

후처리

  1. temperaturewas refluxed for 1 h
  2. filtrationThe mixture was filtered through celite
  3. concentrationconcentrated
  4. dissolutionThe residue was dissolved in chloroform
  5. washthe solution was washed with 1M aqueous NaOH
  6. dry with materialThe organic layer was dried over Na2SO4
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-2d31414e75a44485bee1ef5a92631901
출처 데이터셋
uspto-grants-2001_06
특허 번호
US06248755B1

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