Hydrochloric Acid → 4-(3-Methylphenyl)-4-hydroxypiperidine hydrochloride

HRID 1068396노트

반응식

HRID 1068396 반응식
C(OC([N:8]1[CH2:13][CH2:12][C:11]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([CH3:21])[CH:16]=2)([OH:14])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:22]>CCOC(C)=O>[ClH:22].[CH3:21][C:17]1[CH:16]=[C:15]([C:11]2([OH:14])[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[CH:20]=[CH:19][CH:18]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 21193300N-t-Butoxycarbonyl-4-(3-methylphenyl)-4-hydroxy piperidine

생성물 1

HCID 211931674-(3-Methylphenyl)-4-hydroxypiperidine hydrochloride

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

To a solution of N-t-butoxycarbonyl-4-(3-methylphenyl)-4-hydroxy piperidine (0.546 mg, 1.87 mmol) in EtOAc (30 ml) at 0° C. was bubbled gasseous HCl until saturated. After 10 min the solvent was evaporated in vacuo to afford the title compound of sufficient purity to be used in the next step.

후처리

  1. customAfter 10 min the solvent was evaporated in vacuo

출처 및 근거

ORD 기록
ord-c632c0d9cb5f40bca51a3f24a84aaf96
출처 데이터셋
uspto-grants-2001_06
특허 번호
US06248756B1

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