Malic Acid → 7-Hydroxy-8-methyl coumarin

HRID 1068546

반응식

HRID 1068546 반응식
[CH3:1][C:2]1[C:8]([OH:9])=[CH:7][CH:6]=[CH:5][C:3]=1[OH:4].C(O)(=O)[CH:11]([CH2:13][C:14](O)=O)[OH:12]>S(=O)(=O)(O)O>[OH:4][C:3]1[C:2]([CH3:1])=[C:8]2[C:7]([CH:14]=[CH:13][C:11](=[O:12])[O:9]2)=[CH:6][CH:5]=1

참가 물질

4

반응물 2

HCID 525Malic AcidHCID 118432-Methylresorcinol

생성물 1

HCID 53809787-Hydroxy-8-methyl coumarin수율 20.64%

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매

반응 조건

온도
80 °C

실험 절차

2-methyl resorcinol (0.161 mmol, 20.024 g) and malic acid (0.165 mmol, 22.129 g) were dissolved in concentrated sulfuric acid. The reaction mixture was stirred at 80° C. for 24 h. The resulting solution was then poured over crushed ice, and the precipitate was collected by vacuum filtration. The precipitate was then washed with 5% NaHCO3 and again collected by vacuum filtration yielding an orange-yellow solid in a 20.64% yield.

후처리

  1. additionThe resulting solution was then poured
  2. customover crushed ice
  3. filtrationthe precipitate was collected by vacuum filtration
  4. washThe precipitate was then washed with 5% NaHCO3
  5. filtrationagain collected by vacuum filtration
  6. customyielding an orange-yellow solid in a 20.64% yield

출처 및 근거

ORD 기록
ord-d93ca7e08a9f450c957313863ec655d2
출처 데이터셋
uspto-grants-2001_06
특허 번호
US06251644B1

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