Hydrochloric Acid → 4,5-dihydro-4-(piperidin-4-ylmethyl)-3H-1,4,8b-triazaacenaphthylen-3-one dihydrochloride

HRID 1068782노트

반응식

HRID 1068782 반응식
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][N:15]2[CH2:25][C:24]3[N:26]4[C:17](=[CH:18][N:19]=[C:20]4[CH:21]=[CH:22][CH:23]=3)[C:16]2=[O:27])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:28]>C(O)C>[ClH:28].[ClH:28].[NH:8]1[CH2:13][CH2:12][CH:11]([CH2:14][N:15]2[CH2:25][C:24]3[N:26]4[C:17](=[CH:18][N:19]=[C:20]4[CH:21]=[CH:22][CH:23]=3)[C:16]2=[O:27])[CH2:10][CH2:9]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 99074084,5-Dihydro-4-(1-tert-butoxycarbonylpiperidin-4-ylmethyl)-3H-1,4,8b-triazaacenaphthylen-3-one

생성물 1

HCID 211902714,5-dihydro-4-(piperidin-4-ylmethyl)-3H-1,4,8b-triazaacenaphthylen-3-one dihydrochloride수율 94.2%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution prepared by dissolving 3.71 g (10.0 mM) of 4,5-dihydro-4-(1-tert-butoxycarbonylpiperidin-4-ylmethyl)-3H-1,4,8b-triazaacenaphthylen-3-one in 50 ml of ethanol was added 4.11 ml of 12N-hydrochloric acid at room temperature. This mixture was stirred at room temperature for 1 hour and the resulting precipitate was recovered by filtration. The precipitate was rinsed with a small amount of ether and dried in vacuo to provide 3.24 g (yield 94.2%) of the title compound as white powders.

후처리

  1. customTo a solution prepared
  2. filtrationthe resulting precipitate was recovered by filtration
  3. washThe precipitate was rinsed with a small amount of ether
  4. customdried in vacuo

출처 및 근거

ORD 기록
ord-3493443ba22440cb86875204ae68faa6
출처 데이터셋
uspto-grants-2001_06
특허 번호
US06251905B1

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