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Diisopropylethylamine → (S)-4-Methyl-2-[methyl-(3-methyl-but-2-enyl)-amino]-pentanoic acid

HRID 1069447
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인쇄 미리보기

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HRID 1069447 반응식
[CH3:1][N:2]([C:11](OC(C)(C)C)=O)[C@H:3]([C:8]([OH:10])=[O:9])[CH2:4][CH:5]([CH3:7])[CH3:6].CN(C(ON1N=NC2C=C[CH:31]=[CH:32][C:27]1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.[CH:42](N(C(C)C)CC)(C)C>CC#N>[CH3:7][CH:5]([CH3:6])[CH2:4][C@H:3]([N:2]([CH3:1])[CH2:11][CH:42]=[C:32]([CH3:31])[CH3:27])[C:8]([OH:10])=[O:9]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 81531DiisopropylethylamineHCID 2733084Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 7010555(2S)-2-{[(tert-butoxy)carbonyl](methyl)amino}-4-methylpentanoic acid

생성물 1

HCID 86757058(S)-4-Methyl-2-[methyl-(3-methyl-but-2-enyl)-amino]-pentanoic acid수율 340.9%

시약·촉매·용매 1

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트
HCID 6342
Acetonitrile
용매

실험 절차

A mixture of Ia (0.535 g, 1.65 mmol), N-Methyl-N-Boc-L-Leucine (0.405 g, 1.65 mmol), HBTU (0.625 g, 1.65 mmol), and diisopropylethylamine (0.516 g, 6.6 mmol) was stirred in CH3CN (30 mL) for 15 hours. The reaction mixture was concentrated, redissolved in EtOAc, washed 3 times with saturated sodium bicarbonate solution and once with brine, then concentrated to give 1.2 g of the desired product.

후처리

  1. concentrationThe reaction mixture was concentrated
  2. dissolutionredissolved in EtOAc
  3. washwashed 3 times with saturated sodium bicarbonate solution
  4. concentrationonce with brine, then concentrated

출처 및 근거

ORD 기록
ord-c752f89a232f4a87b821ba16bcddcadc
출처 데이터셋
uspto-grants-2001_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06251918B1

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