Water → 2-Hydroxy-3-phenylaminocarbonyl-6-hydroxycarbonylnaphthalene

HRID 1069819노트

반응식

HRID 1069819 반응식
[C:1]1([NH:7][C:8]([C:10]2[C:11](C([O-])=O)=[CH:12][C:13]3[C:18]([CH:19]=2)=[CH:17][C:16]([C:20]([O:22]C)=[O:21])=[CH:15][CH:14]=3)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Na+].[OH2:28].[OH-].[Na+]>CO>[OH:28][C:11]1[C:10]([C:8]([NH:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[O:9])=[CH:19][C:18]2[C:13](=[CH:14][CH:15]=[C:16]([C:20]([OH:22])=[O:21])[CH:17]=2)[CH:12]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 23666583HCID 23666583, 화합물

생성물 1

HCID 109797242-Hydroxy-3-phenylaminocarbonyl-6-hydroxycarbonylnaphthalene수율 85%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Sodium 3-phenylaminocarbonyl-6-methoxycarbonyl-2-naphthoate (0.081 g) obtained in Example 29 was suspended in methanol (8.10 g) and deionized water (8.13 g) and 1N-sodium hydroxide (4.0 g) was added dropwise under ice-cooling, followed by stirring overnight. The reaction solution was freeze-dried and the resultant solid was dissolved in water. The solution was acidified with diluted hydrochloric acid and the deposited crystal was filtered. The crystal was dried under reduced pressure to obtain 0.057 g of 2-hydroxy-3-phenylaminocarbonyl-6-hydroxycarbonylnaphthalene.

후처리

  1. temperaturecooling
  2. customThe reaction solution was freeze-dried
  3. dissolutionthe resultant solid was dissolved in water
  4. filtrationthe deposited crystal was filtered
  5. customThe crystal was dried under reduced pressure

출처 및 근거

ORD 기록
ord-42205556e5e04dfb9397e0529c173411
출처 데이터셋
uspto-grants-2001_06
특허 번호
US06252104B1

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