Sodium borohydride → 3-Methoxy-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzyl alcohol

HRID 1070086

반응식

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][C:10]=1[O:11][CH2:12][C:13]1[N:14]=[C:15]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[O:16][C:17]=1[CH3:18])[CH:6]=[O:7].[BH4-].[Na+]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][C:10]=1[O:11][CH2:12][C:13]1[N:14]=[C:15]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[O:16][C:17]=1[CH3:18])[CH2:6][OH:7]

참가 물질

반응물 2

HCID 4311764Sodium borohydride

HCID 108297433-Methoxy-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzaldehyde

생성물 1

HCID 573158203-Methoxy-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzyl alcohol수율 93.9%

실험 절차

In substantially the same manner in Reference Example 93, 3-methoxy-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzaldehyde (6.47 g) was reduced by sodium borohydride (760 mg) to obtain 3-methoxy-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzyl alcohol (6.11 g, yield 93%) as crystals.

출처 및 근거

ORD 기록: ord-0560edc9d4964f6ba42313b8b87ff9c2
출처 데이터셋: uspto-grants-2001_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06251926B1

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