Hydrochloric Acid → 2-(N'-(4-hydroxyphenyl)ureido)ethylmethacrylate

HRID 1070371

반응식

HRID 1070371 반응식
[CH:1]1[C:6]([NH2:7])=[CH:5][CH:4]=[C:3]([OH:8])[CH:2]=1.[C:9]([O:14][CH2:15][CH2:16][N:17]=[C:18]=[O:19])(=[O:13])[C:10]([CH3:12])=[CH2:11].[N-]=C=O.Cl>O.CN(C)C(=O)C>[C:9]([O:14][CH2:15][CH2:16][NH:17][C:18]([NH:7][C:6]1[CH:5]=[CH:4][C:3]([OH:8])=[CH:2][CH:1]=1)=[O:19])(=[O:13])[C:10]([CH3:12])=[CH2:11]

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 4034-AminophenolHCID 354092-Isocyanatoethyl methacrylateHCID 105034Isocyanate

생성물 1

HCID 228923762-(N'-(4-hydroxyphenyl)ureido)ethylmethacrylate수율 93.3%

시약·촉매·용매 2

HCID 962Water용매HCID 31374Dimethylacetamide용매

실험 절차

Into a 1 liter fask 500 g of N,N-Dimethyl acetamide and 173.5 g (1.6 mole) of p-aminophenol were added. This mixture was placed in cold bath and 234.9 g (1.5 mole) of methacryloyl oxyethyl isocyanate was added over a period of 1 hour. After the addition was complete, stirring was continued for 5 hours at room temperature. The mixture was tested for isocyanate functionality using IR spectroscopy. 30 ml of concentrated HCl was added to the mixture and was stirred for 15 minutes. The mixture was poured into 4.5 liter of water. The deposit was filtered, washed and dried to produce 370 g of 2-(N′-(4-hydroxyphenyl)ureido)ethyl methacrylate.

후처리

  1. customThis mixture was placed in cold bath
  2. additionAfter the addition
  3. stirringwas stirred for 15 minutes
  4. filtrationThe deposit was filtered
  5. washwashed
  6. customdried

출처 및 근거

ORD 기록
ord-6b78b2288e58467b9dc04b0bfa0cbd18
출처 데이터셋
uspto-grants-2005_06
특허 번호
US06902860B2

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