Sodium Hydroxide → 2'-Methoxy-biphenyl-4-carboxylic acid

HRID 1070416

반응식

HRID 1070416 반응식
C([O:3][C:4]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[O:18][CH3:19])=[CH:8][CH:7]=1)=[O:5])C.[OH-].[Na+]>O1CCCC1>[CH3:19][O:18][C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=1[C:9]1[CH:10]=[CH:11][C:6]([C:4]([OH:5])=[O:3])=[CH:7][CH:8]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 438402982'-Methoxy-biphenyl-4-carboxylic acid ethyl ester

생성물 1

HCID 27595482'-Methoxy-biphenyl-4-carboxylic acid수율 97.4%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of 2′-methoxy-[1,1′-biphenyl]-4-carboxylic acid ethyl ester of Step A (3.7 g, 14.4 mmol) in tetrahydrofuran (40 mL) and 1 N sodium hydroxide (30 mL, 30 mmol) was heated at reflux overnight. After cooling, the reaction mixture was concentrated in vacuo, and the residue was acidified with 2N hydrochloric acid to give a white solid which was collected by filtration and dried under vacuum to provide the title compound (3.2 g, 97.4%) as a white solid, m.p. 250-253° C.

후처리

  1. temperaturewas heated
  2. temperatureat reflux overnight
  3. temperatureAfter cooling
  4. concentrationthe reaction mixture was concentrated in vacuo
  5. customto give a white solid which
  6. filtrationwas collected by filtration
  7. customdried under vacuum

출처 및 근거

ORD 기록
ord-f55b762bdda741a69d85a3996b200959
출처 데이터셋
uspto-grants-2005_06
특허 번호
US06903091B2

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