Trichloroisocyanuric Acid → Methyl 2-(chloromethyl)pyridine-3-carboxylate

HRID 1070430

반응식

HRID 1070430 반응식
[CH3:1][C:2]1[N:11]=[CH:10][CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].[Cl:12]N1C(=O)N(Cl)C(=O)N(Cl)C1=O>ClCCl>[CH3:7][O:6][C:4]([C:3]1[C:2]([CH2:1][Cl:12])=[N:11][CH:10]=[CH:9][CH:8]=1)=[O:5]

참가 물질

4

반응물 2

HCID 6909Trichloroisocyanuric AcidHCID 7015327Methyl 2-methylnicotinate

생성물 1

HCID 19081344Methyl 2-(chloromethyl)pyridine-3-carboxylate수율 45.7%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of methyl 2-methylnicotinate (20.0 g, 0.132 mol) and trichloroisocyanuric acid (46.0 g, 0.198 mol) in dichloromethane (100 mL) was stirred at room temperature overnight. The reaction mixture was then washed with saturated aqueous sodium carbonate and saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate, filtered, and the solvent evaporated in vacuo to provide the title compound as a yellow liquid (11.2 g), which is used as such in the next step.

후처리

  1. washThe reaction mixture was then washed with saturated aqueous sodium carbonate and saturated aqueous sodium chloride
  2. dry with materialdried over anhydrous magnesium sulfate
  3. filtrationfiltered
  4. customthe solvent evaporated in vacuo

출처 및 근거

ORD 기록
ord-030aea0f86e740558a593b5da77d0876
출처 데이터셋
uspto-grants-2005_06
특허 번호
US06903091B2

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